Estrogen Detoxification

Estrogen Detoxification

Description

Estrogen goes through phase 1 and phase 2 detoxification known collectively as estrogen metabolism. A healthy metabolism shunts estrogen into 2-OH-E1 and then through methylation via COMT into 2-methoxy-E1 for proper disposal from the body. Unfortunately, if the pathway turns towards the unhealthy 4-OH-E1 or does not go through methylation, those estrogens go on to form a quinone that can result in DNA damage and increased cancer risk. Certain enzymes, such as Quinone Reductase and Glutathione-S-Transferase, help prevent or reverse quinone formation and can be optimized with specific dietary changes and natural products. It is also important to evaluate the gut as the microbiome has a huge influence on b-glucuronidase and the resulting clearance or reactivation of estrogen into the system. The purpose of this lecture is to review estrogen metabolism, including the genetics involved, the microbiome’s influence and discuss various treatment options to improve both phase 1 and phase 2 detox in order to help reduce cancer risk in both men and women. Cases will be included.

Learning Objectives

  1. Understand how estrogen (endogenous or exogenous) moves through phase 1 and phase 2 detoxification and the snps/enzymes involved in each process.
  2. Review the genetic snps and enzymes involved in each process.
  3. Discuss food sources that have been shown in the literature to improve estrogen metabolism outcomes.
  4. Discuss the microbiome and estrobolome and its influence on estrogen clearance
  5. Discuss natural therapies that have been shown in the literature to improve estrogen metabolism.

Course image by: Doxepine [Public domain], from Wikimedia Commons

Course Content

  • Estrogen Detoxification 45min

Instructor

Carrie Jones, ND, FABNE, MPH is an internationally recognized speaker, consultant, and educator on the topic of women’s health and hormones. Dr. Jones graduated from the National University of Natural Medicine in Portland, Oregon where she also completed a 2-year residency in women’s health, hormones, and endocrinology. Later, she graduated from Grand Canyon University’s Master of Public Health program.

Dr. Jones was one of the first to become board certified through the American Board of Naturopathic Endocrinology. She was adjunct faculty for many years, teaching gynecology and advanced endocrinology/fertility. She was the Medical Director for the DUTCH Test for nine years and recently joined the Lifestyle Matrix Resource Center as the Clinical Expert serving the SOS Stress Recovery Program. Currently, she is the Head of Medical Education at Rupa Health.

Continuing Education Approvals

  • Canadian Federation of Aromatherapists (CFA)

    0.375 CEU total (up to 0.375 CEU Category B) -Direct Approval
  • National Certification Board for Therapeutic Massage & Bodywork (Provider #1583) (NCBTMB)

    1 hour total (up to 1 hour Advanced Science) -Direct Approval
  • New Hampshire Association of Naturopathic Doctors (NHAND)

    0.75 CEU total (up to 0.75 CEU General, up to 0.75 CEU Childbirth) -Direct Approval
  • New York Sponsorship via National Certification Board for Therapeutic Massage & Bodywork (NY NCBTMB)

    1 hour total -Direct Approval
  • Oregon Board of Naturopathic Medicine (OBNM) - (expires on April 20, 2025)

    0.75 hour total (up to 0.75 hour General Education, up to 0.75 hour Natural Childbirth) -Direct Approval
  • Vermont Office of Professional Regulation (VT OPR)

    0.75 hour total (up to 0.75 hour General) -Direct Approval
  • Alliance of International Aromatherapists (AIA)

    0.375 CPD total (up to 0.375 CPD Category B) -Assumed Approval
  • Arizona Naturopathic Physicians Medical Board (AZ NPMB)

    0.75 CME total (up to 0.75 CME General) -Assumed Approval
  • College of Naturopathic Doctors of Alberta (CNDA)

    0.75 continuing competence credit total -Assumed Approval
  • College of Naturopathic Physicians of British Columbia (CNPBC)

    0.75 hour total (up to 0.75 hour Category C - Educational Courses) -Assumed Approval
  • College of Naturopaths of Ontario (CONO)

    0.75 credit total (up to 0.75 credit Category B) -Assumed Approval
  • Colorado Office of Naturopathic Doctor Registration (CO ONDR)

    0.75 PDA total -Assumed Approval
  • Connecticut Department of Public Health: Naturopathic Physician Licensure (CT DPH: NPL)

    0.75 hour total -Assumed Approval
  • Council for Homeopathic Certification (CHC)

    0.75 CEU total (up to 0.75 CEU Category 2) -Assumed Approval
  • District of Columbia Health Regulation and Licensing Administration (DC HRLA)

    0.75 hour total -Assumed Approval
  • Hawaii Department of Commerce and Consumer Affairs Professional & Vocational Licensing (HI DCCA)

    0.75 CE total (up to 0.75 CE General) -Assumed Approval
  • Idaho Board of Medicine: Naturopathic Medical Board (ID BOM: NMB)

    0.75 hour total (up to 0.75 hour General) -Assumed Approval
  • Kansas State Board of Healing Arts (KS SBHA)

    0.75 CEU total -Assumed Approval
  • Maine Board of Complementary Health Care Providers (ME BCHCP)

    0.75 hour total (up to 0.75 hour General) -Assumed Approval
  • Manitoba Naturopathic Association (MNA)

    0.75 hour total (up to 0.75 hour Category B) -Assumed Approval
  • Maryland Board of Physicians (MD BP)

    0.75 hour total -Assumed Approval
  • Minnesota Board of Medical Practice (MN BMP)

    0.75 contact hour total (up to 0.75 contact hour General) -Assumed Approval
  • Montana Board of Alternative Health Care (MT BAHC)

    0.75 hour total (up to 0.75 hour General, up to 0.75 hour Obstetrics) -Assumed Approval
  • North Dakota Board of Integrative Health Care (ND BIHC)

    0.75 credit total (up to 0.75 credit General) -Assumed Approval
  • Rhode Island Department of Health: Board of Medical Licensure and Discipline (RI DOH: BMLD)

    0.75 hour total -Assumed Approval
  • Saskatchewan Association of Naturopathic Practitioners (SANP)

    0.75 hour total (up to 0.75 hour Category C) -Assumed Approval
  • Utah Naturopathic Physician Licensing Board (UT NPLB)

    0.75 CE total (up to 0.75 CE General) -Assumed Approval
  • Washington State Department of Health: Board of Naturopathy (WA DOH: BON)

    0.75 hour total (up to 0.75 hour Category 2) -Assumed Approval
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